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1

Yeast-derived recombinant human insulin-like growth factor I: Production, purification, and structural characterization

Steve Elliott, Katherine D. Fagin, Linda O. Narhi, James A. Miller, Matt Jones, Ray Koski, Mary Peters, Philip Hsieh, Raj Sachdev, Robert D. Rosenfeld, Michael F. Rohde, Tsutomu Arakawa

Journal:

The Protein Journal

Année:

1990

Langue:

english

Fichier:

PDF, 1.11 MB

english, 1990

2

Influence of Dietary Supplementation of Herb Extracts on Volatile Sulfur Production in Pig Large Intestine.

USHIDA, Kazunari, MAEKAWA, Makiko, ARAKAWA, Tsutomu

Journal:

Journal of Nutritional Science and Vitaminology

Année:

2002

Langue:

english

Fichier:

PDF, 1.26 MB

english, 2002

3

Volatile Sulfur Production by Pig Cecal Bacteria in Batch Culture and Screening Inhibitors of Sulfate Reducing Bacteria.

ARAKAWA, Tsutomu, ISHIKAWA, Yoshimi, USHIDA, Kazunari

Journal:

Journal of Nutritional Science and Vitaminology

Année:

2000

Langue:

english

Fichier:

PDF, 1.18 MB

english, 2000

4

Volatile Sulfur Production in the Large Intestine as Affected by Plant Extracts in Pig In Vitro Model

ISHIKAWA, Yoshimi, MAEKAWA, Makiko, ARAKAWA, Tsutomu, USHIDA, Kazunari

Journal:

Bioscience and Microflora

Année:

2001

Langue:

english

Fichier:

PDF, 714 KB

english, 2001

5

Structure, signaling mechanism and regulation of the natriuretic peptide receptor guanylate cyclase

Kunio S. Misono, John S. Philo, Tsutomu Arakawa, Craig M. Ogata, Yue Qiu, Haruo Ogawa, Howard S. Young

Journal:

Année:

2011

Langue:

english

Fichier:

PDF, 601 KB

english, 2011

6

Developments and Challenges for mAb-Based Therapeutics

Goswami, Sumit, Wang, Wei, Arakawa, Tsutomu, Ohtake, Satoshi

Journal:

Année:

2013

Langue:

english

Fichier:

PDF, 1.20 MB

english, 2013

7

Protection of bovine serum albumin from aggregation by Tween 80

Tsutomu Arakawa, Yoshiko Kita

Journal:

Journal of Pharmaceutical Sciences

Année:

2000

Langue:

english

Fichier:

PDF, 432 KB

english, 2000

8

ChemInform Abstract: Applications of Analytical Ultracentrifuge to Molecular Biology and Pharmaceutical Science

Tsutomu Arakawa, John S. Philo

Journal:

Année:

1999

Fichier:

PDF, 25 KB

1999

9

Mechanism of protein precipitation and stabilization by co-solvents

Serge N. Timasheff, Tsutomu Arakawa

Journal:

Journal of Crystal Growth

Année:

1988

Langue:

english

Fichier:

PDF, 540 KB

english, 1988

10

Suppression of protein interactions by arginine: A proposed mechanism of the arginine effects

Tsutomu Arakawa, Daisuke Ejima, Kouhei Tsumoto, Noriyuki Obeyama, Yoshikazu Tanaka, Yoshiko Kita, Serge N. Timasheff

Journal:

Biophysical Chemistry

Année:

2007

Langue:

english

Fichier:

PDF, 391 KB

english, 2007

11

Molecular characterization of ALK, a receptor tyrosine kinase expressed specifically in the nervous system

Iwahara, Toshinori, Fujimoto, Jiro, Wen, Duanzhi, Cupples, Rod, Bucay, Nathan, Arakawa, Tsutomu, Mori, Shigeo, Ratzkin, Barry, Yamamoto, Tadashi

Journal:

Année:

1997

Langue:

english

Fichier:

PDF, 901 KB

english, 1997

12

Mechanism of polyethylene glycol interaction with proteins

Arakawa, Tsutomu, Timasheff, Serge N.

Journal:

Année:

1985

Langue:

english

Fichier:

PDF, 864 KB

english, 1985

13

Solubilization of active green fluorescent protein from insoluble particles by guanidine and arginine

Kouhei Tsumoto, Mitsuo Umetsu, Izumi Kumagai, Daisuke Ejima, Tsutomu Arakawa

Journal:

Biochemical and Biophysical Research Communications

Année:

2003

Langue:

english

Fichier:

PDF, 134 KB

english, 2003

14

Nondenaturing solubilization of β2 microglobulin from inclusion bodies by l-arginine

Mitsuo Umetsu, Kouhei Tsumoto, Shigeki Nitta, Tadafumi Adschiri, Daisuke Ejima, Tsutomu Arakawa, Izumi Kumagai

Journal:

Biochemical and Biophysical Research Communications

Année:

2005

Langue:

english

Fichier:

PDF, 491 KB

english, 2005

15

The effects of arginine on protein binding and elution in hydrophobic interaction and ion-exchange chromatography

Tsutomu Arakawa, Kouhei Tsumoto, Kazuo Nagase, Daisuke Ejima

Journal:

Protein Expression and Purification

Année:

2007

Langue:

english

Fichier:

PDF, 176 KB

english, 2007

16

Screening of effective column rinse solvent for Protein-A chromatography

Ryosuke Yumioka, Kouhei Tsumoto, Tsutomu Arakawa, Daisuke Ejima

Journal:

Protein Expression and Purification

Année:

2010

Langue:

english

Fichier:

PDF, 370 KB

english, 2010

17

The effects of arginine on refolding of aggregated proteins: not facilitate refolding, but suppress aggregation

Tsutomu Arakawa, Kouhei Tsumoto

Journal:

Biochemical and Biophysical Research Communications

Année:

2003

Langue:

english

Fichier:

PDF, 496 KB

english, 2003

18

Efficacy of immunoglobulin plus prednisolone for prevention of coronary artery abnormalities in severe Kawasaki disease (RAISE study): a randomised, open-label, blinded-endpoints trial

Tohru Kobayashi, Tsutomu Saji, Tetsuya Otani, Kazuo Takeuchi, Tetsuya Nakamura, Hirokazu Arakawa, Taichi Kato, Toshiro Hara, Kenji Hamaoka, Shunichi Ogawa, Masaru Miura, Yuichi Nomura, Shigeto Fuse, F

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 209 KB

english, 2012

19

Practical considerations in refolding proteins from inclusion bodies

Kouhei Tsumoto, Daisuke Ejima, Izumi Kumagai, Tsutomu Arakawa

Journal:

Protein Expression and Purification

Année:

2003

Langue:

english

Fichier:

PDF, 172 KB

english, 2003

20

Arginine as a Synergistic Virucidal Agent

Ohtake, Satoshi, Arakawa, Tsutomu, Koyama, A. Hajime

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 512 KB

english, 2010

21

[Methods in Enzymology] Diffraction Methods for Biological Macromolecules Part A Volume 114 || [3]Theory of protein solubility

Arakawa, Tsutomu

Année:

1985

Langue:

english

Fichier:

PDF, 1.25 MB

english, 1985

22

Contribution of the Surface Free Energy Perturbation to Protein-Solvent Interactions

Kita, Yoshiko, Arakawa, Tsutomu, Lin, Tiao-Yin, Timasheff, Serge N.

Journal:

Année:

1994

Langue:

english

Fichier:

PDF, 1.31 MB

english, 1994

23

Induction of α-Helix in the β-Sheet Protein Tumor Necrosis Factor-α: Thermal- and Trifluoroethanol-Induced Denaturation at Neutral pH

Narhi, Linda Owers, Philo, John S., Li, Tiansheng, Zhang, Mei, Samal, Babru, Arakawa, Tsutomu

Journal:

Année:

1996

Langue:

english

Fichier:

PDF, 356 KB

english, 1996

24

Antiviral and Virucidal Activities of Natural Products

Arakawa, Tsutomu, Yamasaki, Hisashi, Ikeda, Keiko, Ejima, Daisuke, Naito, Takeshi, Koyama, A.

Journal:

Current Medicinal Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 648 KB

english, 2009

25

Study on left atrial contractile performance. Participation of Frank-Starling mechanism.

YAMAGUCHI, MASATO, ARAKAWA, MICHIO, TANAKA, TSUTOMU, TAKAYA, TADATAKE, NAGANO, TOSHIHIKO, HIRAKAWA, SENRI

Journal:

Japanese Circulation Journal

Année:

1987

Fichier:

PDF, 852 KB

1987

26

Effects of correcting missing daily feed intake values on the genetic parameters and estimated breeding values for feeding traits in pigs

Ito, Tetsuya, Fukawa, Kazuo, Kamikawa, Mai, Nikaidou, Satoshi, Taniguchi, Masaaki, Arakawa, Aisaku, Tanaka, Genki, Mikawa, Satoshi, Furukawa, Tsutomu, Hirose, Kensuke

Journal:

Animal Science Journal

Année:

2017

Langue:

english

Fichier:

PDF, 209 KB

english, 2017

27

The effects of allantoin, arginine and NaCl on thermal melting and aggregation of ribonuclease, bovine serum albumin and lysozyme

Arakawa, Tsutomu, Maluf, Nasib Karl

Journal:

International Journal of Biological Macromolecules

Année:

2017

Langue:

english

Fichier:

PDF, 1.26 MB

english, 2017

28

Corrigendum to “Mechanism of protein desorption from 4-mercaptoethylpyridine resins by arginine solutions” [J. Chromatogr. A 1373 (2014) 141–148]

Hirano, Atsushi, Maruyama, Takuya, Shiraki, Kentaro, Arakawa, Tsutomu, Kameda, Tomoshi

Journal:

Journal of Chromatography A

Année:

2018

Langue:

english

Fichier:

PDF, 615 KB

english, 2018

29

Applications of Analytical Ultracentrifuge to Molecular Biology and Pharmaceutical Science

ARAKAWA, Tsutomu, PHILO, John S.

Journal:

YAKUGAKU ZASSHI

Année:

1999

Fichier:

PDF, 1.03 MB

1999

30

Aggregation behaviors of glutens, glutenins and gliadins from various wheats.

ARAKAWA, Tsutomu, MORISHITA, Hideaki, YONEZAWA, Daizo

Journal:

Agricultural and Biological Chemistry

Année:

1976

Langue:

english

Fichier:

PDF, 1.22 MB

english, 1976

31

Effects of allantoin and dimethyl sulfoxide on the thermal aggregation of lysozyme

Nishinami, Suguru, Hirano, Atsushi, Arakawa, Tsutomu, Shiraki, Kentaro

Journal:

International Journal of Biological Macromolecules

Année:

2018

Langue:

english

Fichier:

PDF, 934 KB

english, 2018

32

Binding and Elution Properties of Mixed-Mode Chromatography and Its Applications for Purification

Arakawa, Tsutomu, Santarelli, Xavier

Journal:

Current Protein & Peptide Science

Année:

2018

Langue:

english

Fichier:

PDF, 107 KB

english, 2018

33

Insoluble expression of highly soluble halophilic metal binding protein for metal ion biosorption: Application of aggregation-prone peptide from hen egg white lysozyme

Tokunaga, Masao, Arakawa, Tsutomu, Tokunaga, Yuhei, Sugimoto, Yasushi, Ishibashi, Matsujiro

Journal:

Protein Expression and Purification

Année:

2019

Langue:

english

Fichier:

PDF, 1.59 MB

english, 2019

34

Development and clinical application of high performance liquid chromatography for the simultaneous determination of plasma levels of theophylline and its metabolites without interference from caffeine

Junko Kizu, Shigekazu Watanabe, Nobuhiro Yasuno, Yoshihiro Arakawa, Sonoko Uzu, Susumu Kanda, Fusako Komoda, Tsutomu Iwata, Hiroshi Hayakawa, Tetsuo Hayakawa, Kazuhiro Imai

Journal:

Biomedical Chromatography

Année:

1999

Langue:

english

Fichier:

PDF, 131 KB

english, 1999

35

Enhanced theophylline metabolism in patients with bronchial asthma at age 4 and under

Junko Kizu, Motoki Arakawa, Yoshihiro Arakawa, Fusako Komoda, Masaru Takamizawa, Tsutomu Iwata, Tetsuo Hayakawa, Kazuhiro Imai

Journal:

Biomedical Chromatography

Année:

1999

Langue:

english

Fichier:

PDF, 69 KB

english, 1999

36

Changes in protein conformation and dynamics upon complex formation of brain-derived neurotrophic factor and its receptor: Investigation by isotope-edited Fourier transform IR spectroscopy

Tiansheng Li, Jane Talvenheimo, Lisa Zeni, Robert Rosenfeld, George Stearns, Tsutomu Arakawa

Journal:

Année:

2002

Langue:

english

Fichier:

PDF, 189 KB

english, 2002

37

Fourier transform infared spectroscopy investigation of protein conformation in spray-dried protein/trehalose powders

Donna L. French, Tsutomu Arakawa, Tiansheng Li

Journal:

Année:

2004

Langue:

english

Fichier:

PDF, 125 KB

english, 2004

38

Polyethylene glycol behaves like weak organic solvent

Atsushi Hirano, Kentaro Shiraki, Tsutomu Arakawa

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 194 KB

english, 2012

39

Effect of cosolvents on solubility of protein in equilibrium between different states

Tsutomu Arakawa

Journal:

Année:

1987

Langue:

english

Fichier:

PDF, 601 KB

english, 1987

40

The stabilization of β-lactoglobulin by glycine and NaCl

Tsutomu Arakawa

Journal:

Année:

1989

Langue:

english

Fichier:

PDF, 263 KB

english, 1989

41

Reversibility of acid denaturation of recombinant interferon-γ

Tsutomu Arakawa, Yeuh-Rong Hsu, Michael A. Narachi, Charles Herrera, Michael F. Rohde, Paul Hennigan

Journal:

Année:

1990

Langue:

english

Fichier:

PDF, 270 KB

english, 1990

42

Hydrophobic interaction chromatography in dual salt system increases protein binding capacity

Anna M. Senczuk, Ralph Klinke, Tsutomu Arakawa, Ganesh Vedantham, Yinges Yigzaw

Journal:

Biotechnology and Bioengineering

Année:

2009

Langue:

english

Fichier:

PDF, 198 KB

english, 2009

43

The Effects of Protein Stabilizers on Aggregation Induced by Multiple-Stresses

Tsutomu Arakawa, Daniel Bernhard Dix, Byeong Seon Chang

Journal:

Année:

2004

Fichier:

PDF, 54 KB

2004

44

ChemInform Abstract: Role of Arginine in Development of Biopharmaceuticals

Tsutomu Arakawa

Journal:

Année:

2010

Fichier:

PDF, 14 KB

2010

45

Helicobacter pylori infection appears the prime risk factor for stomach cancer

Shinkan Tokudome, Reza Ghadimi, Sadao Suzuki, Akihiro Hosono, Tsutomu Tanaka, Kazuyuki Arakawa, Yang Zhao, Nami Hattori, Hiroyuki Agawa, Mitsuhiro Marumoto, Ryosuke Ando, Malcolm A. Moore

Journal:

International Journal of Cancer

Année:

2006

Langue:

english

Fichier:

PDF, 44 KB

english, 2006

46

Simultaneous determination of metabolites of trimethylbenzenes, dimethylbenzylmercapturicacid and dimethylhippuric acid, in human urine by solid-phase extraction followed by liquid chromatography tandem mass spectrometry

Hiroshi Moriwaki, Ayumi Watanabe, Ryuichi Arakawa, Yuji Tsujimoto, Mitsuru Shimizu, Tsutomu Noda, Munehiro Warashina, Masanobu Tanaka

Journal:

Journal of Mass Spectrometry

Année:

2002

Langue:

english

Fichier:

PDF, 118 KB

english, 2002

47

Effects of salts on protein–surface interactions: applications for column chromatography

Kouhei Tsumoto, Daisuke Ejima, Anna M. Senczuk, Yoshiko Kita, Tsutomu Arakawa

Journal:

Journal of Pharmaceutical Sciences

Année:

2007

Langue:

english

Fichier:

PDF, 280 KB

english, 2007

48

Arginine facilitates inactivation of enveloped viruses

Hisashi Yamasaki, Kazuko Tsujimoto, A. Hajime Koyama, Daisuke Ejima, Tsutomu Arakawa

Journal:

Journal of Pharmaceutical Sciences

Année:

2008

Langue:

english

Fichier:

PDF, 127 KB

english, 2008

49

Development of Calcitonin Salmon Nasal Spray: Similarity of peptide formulated in chlorobutanol compared to benzalkonium chloride as preservative

Henry R. Costantino, Heather Culley, Lishan Chen, Daniel Morris, Michael Houston, Sharin Roth, Mary Jo Phoenix, Chuck Foerder, John S. Philo, Tsutomu Arakawa, Lisa Eidenschink, Niels H. Andersen, Gord

Journal:

Journal of Pharmaceutical Sciences

Année:

2009

Langue:

english

Fichier:

PDF, 332 KB

english, 2009

50

The critical role of mobile phase composition in size exclusion chromatography of protein pharmaceuticals

Tsutomu Arakawa, Daisuke Ejima, Tiansheng Li, John S. Philo

Journal:

Journal of Pharmaceutical Sciences

Année:

2010

Langue:

english

Fichier:

PDF, 329 KB

english, 2010